Ash and friends arrive on an island where they run into Blackthorn Gym Leader Clair who is looking for her Dragonite.
An army of Genesect swarm a seaside city causing troubles for their power supply. This attracts the attention of Mewtwo who comes to battle them.
Ash and friends follow Alexa to a deserted island to help solve the mystery of a sunken ship.
Ash and friends meet a trainer and journalist named Alexa who is from the Kalos region.